HAP I/II (All units)
Pharmaceutical Analysis I (All units)
Pharmaceutics
Unit 1: Notes
A) Introduction to dosage form notes PPT
Unit 2: Notes
SET 1 (Q1–Q10)
Pharmacology of Cardiovascular System – Basics, CHF, Antihypertensives
1. Which of the following best describes preload?
a) Resistance against ventricular ejection
b) Volume of blood in ventricles at the end of diastole
c) Pressure during ventricular contraction
d) Heart rate per minute
2. SA node acts as the pacemaker of the heart because:
a) It has fastest conduction
b) It has lowest threshold potential
c) It has highest rate of spontaneous depolarization
d) It is centrally located
3. Digoxin increases cardiac output primarily by:
a) Beta-1 receptor stimulation
b) Increasing sodium excretion
c) Inhibiting Na⁺/K⁺ ATPase
d) Blocking calcium channels
4. Which drug is preferred in acute left ventricular failure?
a) Atenolol
b) Digoxin
c) Furosemide
d) Atorvastatin
5. ACE inhibitors reduce blood pressure by:
a) Blocking renin release
b) Inhibiting angiotensin II formation
c) Increasing calcium influx
d) Blocking beta receptors
6. Which of the following is a calcium channel blocker?
a) Propranolol
b) Nifedipine
c) Captopril
d) Prazosin
7. Nitroglycerin relieves angina mainly by:
a) Increasing contractility
b) Coronary vasoconstriction
c) Venodilation → reducing preload
d) Blocking potassium channels
8. A drug used in variant (Prinzmetal) angina is:
a) Atenolol
b) Amlodipine
c) Nitric oxide
d) Adenosine
9. Amiodarone belongs to which class of antiarrhythmics?
a) Class I
b) Class II
c) Class III
d) Class IV
10. Statins reduce cholesterol mainly by:
a) Inhibiting intestinal fat absorption
b) Inhibiting HMG-CoA reductase
c) Increasing bile acid secretion
d) Blocking chylomicron formation
SET 2 (Q11–Q20)
CVS Drugs – Shock, Coagulants, Anticoagulants, Fibrinolytics
11. Which drug is most commonly used in anaphylactic shock?
a) Atropine
b) Dopamine
c) Adrenaline
d) Dobutamine
12. Treatment of hypovolemic shock includes:
a) Vasopressin
b) Plasma expanders
c) Antihistamines
d) Digoxin
13. Which of the following is an oral anticoagulant?
a) Heparin
b) Warfarin
c) Streptokinase
d) Protamine
14. Mechanism of action of heparin is:
a) Vitamin K inhibition
b) Direct thrombin activation
c) Activation of antithrombin III
d) Platelet aggregation
15. Streptokinase acts by:
a) Inhibiting fibrin formation
b) Activating plasminogen to plasmin
c) Inhibiting factor Xa
d) Neutralizing thrombin
16. Which drug is an antiplatelet agent?
a) Clopidogrel
b) Heparin
c) Alteplase
d) Folic acid
17. Hematinics include all EXCEPT:
a) Iron
b) Vitamin B12
c) Folic acid
d) Heparin
18. Which drug is used to reverse heparin overdose?
a) Protamine sulfate
b) Vitamin K
c) Warfarin
d) Atropine
19. Dextran is classified as:
a) Anticoagulant
b) Coagulant
c) Plasma volume expander
d) Fibrinolytic agent
20. Aspirin inhibits platelet aggregation by blocking:
a) COX-1 → ↓TxA₂
b) COX-2 → ↓PGI₂
c) Thrombin
d) Factor VIII
SET 3 (Q21–Q30)
Diuretics & Antidiuretics
21. Loop diuretics act mainly on:
a) Proximal tubule
b) Distal tubule
c) Loop of Henle (thick ascending limb)
d) Collecting duct
22. Which of the following is a loop diuretic?
a) Mannitol
b) Furosemide
c) Spironolactone
d) Hydrochlorothiazide
23. Thiazide diuretics mainly inhibit:
a) Na⁺/K⁺/2Cl⁻ cotransporter
b) Na⁺/Cl⁻ cotransporter
c) Aldosterone receptors
d) Carbonic anhydrase
24. Spironolactone is a:
a) Potassium-sparing diuretic
b) Loop diuretic
c) Thiazide
d) Osmotic diuretic
25. Which diuretic is preferred in cerebral edema?
a) Mannitol
b) Furosemide
c) Chlorthalidone
d) Spironolactone
26. ADH acts mainly on:
a) Loop of Henle
b) Glomerulus
c) Collecting duct
d) Proximal tubule
27. Vasopressin is used to treat:
a) Diabetes mellitus
b) Diabetes insipidus
c) Heart failure
d) Hypertension
28. A diuretic causing hyperkalemia:
a) Furosemide
b) Spironolactone
c) Mannitol
d) Chlorthalidone
29. A side effect of thiazide diuretics is:
a) Hyperuricemia
b) Hypoglycemia
c) Hyperkalemia
d) Bradycardia
30. Conivaptan is classified as:
a) V1 receptor agonist
b) V2 receptor antagonist
c) Beta agonist
d) Aldosterone antagonist
SET 4 (Q31–Q40)
Autacoids – Histamine, 5-HT, Prostaglandins, Leukotrienes
31. Histamine released from mast cells acts mainly on:
a) H₁ receptors
b) H₂ receptors
c) H₃ receptors
d) H₄ receptors
32. Diphenhydramine belongs to:
a) H₁ antagonist (1st generation)
b) H₂ antagonist
c) Leukotriene blocker
d) Serotonin agonist
33. Serotonin (5-HT) causes:
a) Bronchodilation
b) Vasodilation
c) Platelet aggregation
d) Hypoglycemia
34. Which drug is a 5-HT₃ antagonist?
a) Ondansetron
b) Sumatriptan
c) Ergotamine
d) Loratidine
35. Leukotrienes mainly cause:
a) Bronchodilation
b) Vasodilation
c) Bronchoconstriction
d) Increased urination
36. Misoprostol is a:
a) PGF₂α analogue
b) PGE₁ analogue
c) Leukotriene blocker
d) TXA₂ inhibitor
37. Montelukast acts by blocking:
a) H₁ receptors
b) COX enzymes
c) Leukotriene receptors
d) Serotonin receptors
38. Kallikrein converts:
a) Bradykinin to inactive form
b) Kininogen → bradykinin
c) Angiotensin I → II
d) Prostaglandin → thromboxane
39. Substance P is mainly involved in:
a) Pain transmission
b) Blood coagulation
c) Bronchodilation
d) Platelet activation
40. Which drug is used in acute migraine attacks?
a) Ondansetron
b) Sumatriptan
c) Ranitidine
d) Ketorolac
SET 5 (Q41–Q50)
NSAIDs, Anti-Gout, Anti-Rheumatic Drugs
41. NSAIDs act primarily by inhibiting:
a) Phosphodiesterase
b) Cyclooxygenase enzymes
c) Renin
d) Bradykinin
42. Which is a selective COX-2 inhibitor?
a) Ibuprofen
b) Naproxen
c) Etoricoxib
d) Aspirin
43. A major adverse effect of NSAIDs is:
a) Hypotension
b) Gastric ulcer
c) Hypoglycemia
d) Cough
44. Allopurinol reduces uric acid by inhibiting:
a) COX-1
b) Xanthine oxidase
c) Renin
d) Lipoxygenase
45. Colchicine is used in:
a) Acute gout
b) Chronic gout
c) Hypertension
d) Arrhythmias
46. Methotrexate is primarily used in:
a) Osteoporosis
b) Rheumatoid arthritis
c) Migraine
d) Peptic ulcer
47. Which drug increases uric acid excretion?
a) Colchicine
b) Allopurinol
c) Probenecid
d) Aspirin (high dose)
48. Aspirin at low doses is used as:
a) Anticoagulant
b) Antiplatelet
c) Antianginal
d) Bronchodilator
49. A DMARD used in rheumatoid arthritis:
a) Paracetamol
b) Methotrexate
c) Ibuprofen
d) Naproxen
50. Indomethacin is used in:
a) Closure of PDA
b) Hypertension
c) Migraine prophylaxis
d) Shock
ANSWER KEY
SET 1 (Q1–Q10)
-
b
-
c
-
c
-
c
-
b
-
b
-
c
-
b
-
c
-
b
SET 2 (Q11–Q20)
-
c
-
b
-
b
-
c
-
b
-
a
-
d
-
a
-
c
-
a
SET 3 (Q21–Q30)
-
c
-
b
-
b
-
a
-
a
-
c
-
b
-
b
-
a
-
b
SET 4 (Q31–Q40)
-
a
-
a
-
c
-
a
-
c
-
b
-
c
-
b
-
a
-
b
SET 5 (Q41–Q50)
-
b
-
c
-
b
-
b
-
a
-
b
-
c
-
b
-
b
-
a
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